Elucidation of general principles for limb regeneration and perfect skin regeneration
Description: Xenopus, a model amphibian, forms a regeneration blastema after limb amputation and then regenerates a limb at last. Xenopus also regenerates skin almost completely after a deep skin injury extent to dermis without forming a scar. We labeled subcutaneous tissues with GFP and indicated that blastema-like cells derived from subcutaneous tissues migrate to the wound and then contribute to skin regeneration. Then, collaborators and I revealed that an Iberian ribbed newt also regenerates skin after deep injury. Furthermore, we identified some groups of genes which are commonly expressed both in limb regeneration and skin regeneration by RNA-seq analysis in Xenupus.
Amount: ¥17,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Hitoshi Yokoyama
Institution: Hirosaki University
Funded outputs count: 8
Funder award ID: 16H04790
OpenAlex ID: G8095944356