Get started
Award

R01 DK078757

Funded outputs count: 33
Funder award ID: R01 DK078757
OpenAlex ID: G810438330
Knockout of Nephron ATP6AP2 Impairs Proximal Tubule Function and Prevents High-Fat Diet-Induced Obesity in Male Mice
2021 · Silas A Culver, Safia Akhtar, et al. · Endocrinology · 6
PDF
Novel regulation of renal gluconeogenesis by Atp6ap2 in response to high fat diet via PGC1-α/AKT-1 pathway
2021 · Safia Akhtar, Silas A. Culver, et al. · Scientific Reports · 15
PDF
Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney
2019 · Safia Akhtar, Helmy M. Siragy · PLoS ONE · 57
PDF
(Pro)renin receptor contributes to renal mitochondria dysfunction, apoptosis and fibrosis in diabetic mice
2019 · Caixia Li, Luis C. Matavelli, et al. · Scientific Reports · 24
PDF
Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene
2018 · Lucia Russo, Harrison T. Muturi, et al. · Molecular Metabolism · 17
PDF
Prorenin receptor mediates inflammation in renal ischemia
2017 · Syed S Quadri, Silas Culver, et al. · Clinical and Experimental Pharmacology and Physiology · 13
Intrarenal Angiotensin-Converting Enzyme: the Old and the New
2017 · Silas Culver, Caixia Li, et al. · Current Hypertension Reports · 44
Autophagy upregulates (pro)renin receptor expression via reduction of P62/SQSTM1 and activation of ERK1/2 signaling pathway in podocytes
2017 · Caixia Li, Helmy M. Siragy · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 12
PDF
(Pro)renin receptor contributes to regulation of renal epithelial sodium channel
2016 · Syed Quadri, Helmy M. Siragy · Journal of Hypertension · 36
Interaction of the renin angiotensin and cox systems in the kidney
2016 · Helmy M Siragy · Frontiers in Bioscience-Scholar · 27
High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion
2015 · Caixia Li, Silas A. Culver, et al. · American Journal of Physiology-Endocrinology and Metabolism · 25
PDF
Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E 2 to F 2 α in conscious diabetic rats
2015 · Peter M Abadir, Helmy M Siragy · Journal of the Renin-Angiotensin-Aldosterone System · 2
PDF
Nephron-specific deletion of the prorenin receptor causes a urine concentration defect
2015 · Nirupama Ramkumar, Deborah Stuart, et al. · American Journal of Physiology-Renal Physiology · 65
AT2 Receptor Activities and Pathophysiological Implications
2015 · Luis C. Matavelli, Helmy M. Siragy · Journal of Cardiovascular Pharmacology · 123
A Nonpeptide Angiotensin II Type 2 Receptor Agonist Prevents Renal Inflammation in Early Diabetes
2015 · Luis C. Matavelli, Roberto Zatz, et al. · Journal of Cardiovascular Pharmacology · 32
Regulation of (pro)renin receptor expression in mIMCD via the GSK-3β-NFAT5-SIRT-1 signaling pathway
2014 · Syed Quadri, Helmy M. Siragy · American Journal of Physiology-Renal Physiology · 21
High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway
2014 · Caixia Li, Helmy M. Siragy · PLoS ONE · 72
PDF
Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro)Renin Receptor via CREB Family and NF-κB Transcription Factors
2013 · Jiqian Huang, Kelly J. Ledford, et al. · Hypertension · 33
Reduction of Aldosterone Production Improves Renal Oxidative Stress and Fibrosis in Diabetic Rats
2012 · Luis C. Matavelli, Helmy M. Siragy · Journal of Cardiovascular Pharmacology · 23
Sodium Depletion Enhances Renal Expression of (Pro)Renin Receptor via Cyclic GMP-Protein Kinase G Signaling Pathway
2011 · Jiqian Huang, Helmy M. Siragy · Hypertension · 46
Combined Aliskiren and Amlodipine Reduce Albuminuria via Reduction in Renal Inflammation in Diabetic Rats
2011 · Luis C. Matavelli, Jiqian Huang, et al. · Journal of Cardiovascular Pharmacology · 10
Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor‐β1 – connective tissue growth factor signalling cascade
2011 · Jiqian Huang, Luis C Matavelli, et al. · Clinical and Experimental Pharmacology and Physiology · 45
Angiotensin AT 2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension
2010 · Luis C. Matavelli, Jiqian Huang, et al. · Hypertension · 150
ESCAPE: From Hypertension to Renal Failure
2010 · Helmy M. Siragy · Current Hypertension Reports · 3
Regulation of (Pro)Renin Receptor Expression by Glucose-Induced Mitogen-Activated Protein Kinase, Nuclear Factor-κB, and Activator Protein-1 Signaling Pathways
2010 · Jiqian Huang, Helmy M. Siragy · Endocrinology · 53
Year
Topic