Generation of a marmoset model of normal tension glaucoma and investigation into neuroprotection and neuroregeneration for glaucoma therapy
Description: The most common cause of blindness in Japan is glaucoma. Normal tension glaucoma (NTG) is a subtype of glaucoma that presents with statistically normal intraocular pressure (IOP), suggesting that non-IOP-dependent factors may contribute to the disease progression. Interestingly, 70% of glaucoma patients in Japan have NTG. In this project, we demonstrated that some existing drugs, nutrients that suppress oxidative stress and caloric restriction are effective for suppression of retinal degeneration in mouse models of glaucoma. In addition, we found that some aged marmosets, non-human primates, develop spontaneous NTG and we are preparing for generation of genetically modified NTG marmosets.
Amount: ¥16,770,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: Takayuki HARADA
Institution: Tokyo Metropolitan Institute of Medical Science
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 26
Funder award ID: 15H04999
OpenAlex ID: G8110500445