Protein Kinase Signaling in the Genotoxic Stress Response
Description: Project Narrative Human tumors frequently develop following environmental exposure to toxins and xenobiotics. These compounds result in DNA damage to epithelial cells and induce an inflammatory microenvironment. We believe that the protein kinase MK2, and a subset of critical RNA-binding proteins function as lynchpins connecting inflammation to cancer, and that therapeutic targeting of these molecule will both reduce the incidence of tumor formation in response to environmental/inflammatory stimuli, and dramatically enhance the ability of tumor cells to be killed by conventional anti-cancer agents. We also propose to characterize a poorly understood RNA damage response that is induced by environmental stress.
Funding type: research
Funder scheme: R35
Start date: 2017-09-01
End date: 2025-07-31
Investigator: MICHAEL B YAFFE
Institution: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Funded outputs count: 52
Funder award ID: R35ES028374
OpenAlex ID: G5668745269