Alzheimer´s Disease pathology within the ageing physiology
Description: Late onset Alzheimer’s disease (AD) may have a long natural history and the search for peripheral biomarkers that could be used for screening in the preclinical phase of the disease is a major challenge. Ageing is the major risk factor for AD and the most recent conceptualizations of ageing and age-related diseases, including neurodegeneration and AD, indicate that they share basic mechanisms, e.g. (neuro)-inflammaging. Thus, to better understand AD pathogenesis and to identify such early biomarkers capable of distinguishing AD from physiological ageing without dementia, it is mandatory to fully posit AD within the framework of ageing process and to study LONGITUDINAL COHORTS OF PRESYMPTOMATIC INDIVIDUALS. The main goal of ADAGE is to identify preclinical circulating biomarkers deviating from healthy ageing trajectories towards AD. To this aim the project will adopt the innovative strategy of comparing extreme phenotypes, i.e. blood samples from AD patients collected years before the clinical onset of the disease versus blood samples from DEMENTIA-FREE CENTENARIANS and their offspring (CO) who maintain a good cognitive status despite their very advanced age. Accordingly, ADAGE will exploit two unique, large and very informative EXISTING COHORTS where biomaterials (blood, plasma, serum and brains) are available and whole genome genetic and epigenetic studies (as well other omics investigations) have been recently performed: i) old TWINS OF THE SWEDISH TWIN REGISTRY
Funder: Vetenskapsrådet
Amount: SEK 4,265,000
Funding type: research
Funder scheme: Project grant
Start date: 2015-12-01
End date: 2018-11-30
Investigator: Nancy Pedersen
Institution: Karolinska Institutet
Funded outputs count: 12
Funder award ID: 2015-06796
OpenAlex ID: G8131812934