Dissecting genetic basis for competitive regulation of tumorigenesis
Description: In Drosophila imaginal epithelium, clones of cells deficient for apico-basal polarity are actively eliminated from the tissue as “losers” of cell competition. During cancer development and progression, such loser cells would acquire further mutations that convert them from “losers” to “winners”. In this study, we found that JNK-mediated regulation of the Hippo pathway component Warts plays a important role in the loser-to-winner switching of the oncogenic mutant cells. Furthermore, we searched through a Drosophila genetic screen for genes involved in the loser-to-winner switching and identified a cell-surface ligand and its receptor, as well as a series of genes involved in neuronal axon guidance, as responsible genes for the competitive regulation of tumorigenesis.
Amount: ¥19,370,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2012-04-01
End date: 2015-03-31
Investigator: Tatsushi IGAKI
Institution: Kyoto University(2013-2014)Kobe University(2012)
Subfield: Cell Biology
Domain: Life Sciences
Funded outputs count: 5
Funder award ID: 24300331
OpenAlex ID: G8164662258