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Senescence cells as a source of pro-aging miR-146a

Description: Narrative Identifying the mechanism and/or causes of extended longevity and delayed aging is one of the greatest scientific challenges of the 21st century. Do these mechanism involve genetics, lifestyle or dietary choices? If one could identify the mechanism involved, future research would have targets to extend lifespan and improve the “healthspan” of the human race.
Funding type: research
Funder scheme: R56
Start date: 2019-09-01
End date: 2021-05-31
Investigator: JAMES L. KIRKLAND
Institution: UNIVERSITY OF CENTRAL FLORIDA
Subfield: Physiology
Field: Medicine
Funded outputs count: 26
Funder award ID: R56AG061414
OpenAlex ID: G818803608
Translating cellular senescence research into clinical practice for metabolic disease
2025 · Selim Chaib, Allyson K. Palmer, et al. · Nature Reviews Endocrinology · 14
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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
2024 · Selim Chaib, José Alberto López-Domínguez, et al. · Nature Cancer · 114
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Potential Clinical Implications of Senotherapies for Cardiovascular Disease
2023 · Masayoshi Suda, Goro Katsuumi, et al. · Circulation Journal · 35
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
2023 · Masayoshi Suda, Karl H. Paul, et al. · Cells · 114
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microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling
2023 · Sarah Noureddine, Jia Nie, et al. · Proceedings of the National Academy of Sciences · 16
The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2
2022 · Selim Chaib, José Alberto López-Domínguez, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7
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Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
2022 · Yu Sun, Qingfeng Li, et al. · Life Medicine · 105
Cellular senescence and senolytics: the path to the clinic
2022 · Selim Chaib, Tamar Tchkonia, et al. · Nature Medicine · 1,084
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Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
2022 · Jéssica D. Hense, Driele N. Garcia, et al. · GeroScience · 36
Plasma miRNA Profile of Crohn’s Disease and Rheumatoid Arthritis Patients
2022 · Tatiana D. Saccon, Joseph M. Dhahbi, et al. · Biology · 14
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miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes
2021 · Allancer D. C. Nunes, Moritz Weigl, et al. · GeroScience · 36
Strategies for late phase preclinical and early clinical trials of senolytics
2021 · Erin O. Wissler Gerdes, Avanish Misra, et al. · Mechanisms of Ageing and Development · 99
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Growth Hormone Signaling Shapes the Impact of Environmental Temperature on Transcriptomic Profile of Different Adipose Tissue Depots in Male Mice
2021 · Augusto Schneider, Berta Victoria, et al. · The Journals of Gerontology Series A · 5
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
2021 · Utkarsh Tripathi, Avanish Misra, et al. · Mechanisms of Ageing and Development · 104
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Circulating microRNA profile in humans and mice with congenital GH deficiency
2021 · Tatiana D. Saccon, Augusto Schneider, et al. · Aging Cell · 24
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries
2021 · Tatiana D. Saccon, Monique T. Rovani, et al. · GeroScience · 14
Specific PIWI-Interacting RNAs and Related Small Noncoding RNAs Are Associated With Ovarian Aging in Ames Dwarf (df/df) Mice
2021 · Joseph M Dhahbi, Joe W Chen, et al. · The Journals of Gerontology Series A · 6
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
2021 · Tatiana Dandolini Saccon, Ravinder Nagpal, et al. · The Journals of Gerontology Series A · 247
Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice
2020 · Zachary R. Hettinger, Amy L. Confides, et al. · Experimental Gerontology · 12
The Interconnections Between Somatic and Ovarian Aging in Murine Models
2020 · Augusto Schneider, Tatiana D Saccon, et al. · The Journals of Gerontology Series A · 18
17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner
2020 · Silvana Sidhom, Augusto Schneider, et al. · The Journals of Gerontology Series A · 24
Discovery, development, and future application of senolytics: theories and predictions
2020 · Erin O. Wissler Gerdes, Yi Zhu, et al. · FEBS Journal · 160
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Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice
2020 · Tatiana Dandolini Saccon, Monique Tomazele Rovani, et al. · Experimental Gerontology · 19
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice
2020 · Marcelo B. Cavalcante, Tatiana D. Saccon, et al. · Aging · 80
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The Role of Ames Dwarfism and Calorie Restriction on Gut Microbiota
2019 · Denise S Wiesenborn, Eric J C Gálvez, et al. · The Journals of Gerontology Series A · 18
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