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Tau-induced astrocyte senescence in Alzheimer's disease

Description: Accumulation of cells undergoing senescence during aging compromises tissue function; astrocytes, critical for brain function, display markers of senescence in Alzheimer’s disease (AD). We discovered that pathogenic tau protein causally implicated in AD potently induces senescence by its transmission to astrocytes. By defining the role of pathogenic tau-induced astrocyte senescence in AD we will open up a completely new avenue of investigation that will contribute urgently needed tools to treat AD and potentially other dementias.
Funding type: research
Funder scheme: RF1
Start date: 2020-09-15
End date: 2024-08-31
Investigator: VERONICA GALVAN
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Subfield: Physiology
Field: Medicine
Funded outputs count: 15
Funder award ID: RF1AG068283
OpenAlex ID: G3481433713
Correction to “A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver”
2026 · Aging Cell
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A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver
2026 · Sabira Mohammed, Chao Jiang, et al. · Aging Cell · 3
Regulation of survival, growth, and metabolism by neuronal mTOR
2026 · Stacy A. Hussong, Raquel Burbank Roberts, et al. · GeroScience
Mitochondrial Ca 2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain
2025 · Jenna Gray, Girish Halemirle, et al. · The Journal of Physiology · 2
Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning
2023 · Hadyn M. Rose, Beatriz Ferrán, et al. · Journal of Neurochemistry · 10
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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy
2023 · Stacy A. Hussong, Andy Q. Banh, et al. · Nature Communications · 85
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Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer’s disease
2023 · Candice E. Van Skike, Nicholas DeRosa, et al. · GeroScience · 19
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Effect of Nrf2 loss on senescence and cognition of tau-based P301S mice
2023 · Ruben Riordan, Wang Rong, et al. · GeroScience · 15
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Henipaviruses: an expanding global public health concern?
2022 · Jorge Quarleri, Verónica Galvan, et al. · GeroScience · 42
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Brain cellular senescence in mouse models of Alzheimer’s disease
2022 · Angela O. Dorigatti, Ruben Riordan, et al. · GeroScience · 31
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease
2021 · Candice E. Van Skike, Stacy A. Hussong, et al. · Journal of Neuroscience · 59
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Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging
2020 · Angela O. Dorigatti, Stacy A. Hussong, et al. · GeroScience · 2
Cerebrovascular dysfunction links aging to neurological disease
2020 · Candice E. Van Skike, Veronica Galvan · Aging · 2
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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
2019 · Candice E. Van Skike, Ai‐Ling Lin, et al. · Aging Cell · 80
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Glial alterations from early to late stages in a model of A lzheimer's disease: Evidence of autophagy involvement in A β internalization
2015 · Carlos Pomilio, Patricio Pavia, et al. · Hippocampus · 80
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