Mass Spectrometric Studies of Neuropeptides in Feeding
Description: PROJECT NARRATIVE The growing incidence of eating disorders and obesity, and their associated health costs have led to intensive research efforts directed at understanding the mechanisms and signaling pathways that control and regulate food intake. This competitive renewal grant application aims at developing innovative mass spectrometry- based technologies and strategies in combination with physiological approaches to characterize neuropeptides and biogenic amines involved in feeding with increased sensitivity, accuracy and throughput. The molecular insights gained from this research promise to increase our knowledge about peptidergic signaling and neuromodulation in the regulation of this essential physiological process, which could ultimately lead to the development of new therapeutic strategies for obesity and eating disorders that have become a big concern of modern societies.
Funding type: research
Funder scheme: R01
Start date: 2006-05-01
End date: 2027-02-28
Investigator: LINGJUN LI
Institution: UNIVERSITY OF WISCONSIN-MADISON
Funded outputs count: 371
Funder award ID: R01DK071801
OpenAlex ID: G9000879955