A high throughput assay to identify novel chromatin factors that regulate DNA repair
Description: Our cells are constantly exposed to spontaneous insults that generate DNA lesions, which if unrepaired, could lead to gene mutations that drives numerous diseases, including cancer, neurodegeneration and immunologic syndromes. Higher organisms have evolved sophisticated mechanisms of DNA repair that support life as we know it. In this regard, our DNA is packed inside our cells in a compact structure termed chromatin, and such structure needs to undergo dynamic changes in order for repair factors to efficiently fix DNA lesions. In this proposal, we aim to develop a novel high-throughput methodology to identify key chromatin factors involved in DNA repair.
Funding type: research
Funder scheme: R21
Start date: 2018-09-01
End date: 2020-08-31
Investigator: RAUL MOSTOSLAVSKY
Institution: MASSACHUSETTS GENERAL HOSPITAL
Funded outputs count: 7
Funder award ID: R21ES027931
OpenAlex ID: G2585776064