Systemic Cell Senescence as a Mediator of Brain Aging Through Circulation
Description: PROJECT NARRATIVE Age is the primary risk factor for cognitive decline, and the number of people with age-related dementia is expected to triple to 14 million by 2050 with no effective treatment solutions on the horizon. This research may demonstrate that senescent cells that accumulate with age throughout the body are a source of pro-aging proteins in blood circulation that disrupt brain function. Systemic elimination of senescent cells may reveal a vital new strategy to deplete the progeronic impact of aged blood, ultimately promoting healthy cognitive aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2021-05-01
End date: 2026-07-31
Investigator: MARISSA JOY SCHAFER
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 9
Funder award ID: R01AG071686
OpenAlex ID: G9000856815