Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
Description: PROJECT NARRATIVE Epidemiological studies have identified strong links between short sleep, the metabolic syndrome and diabetes, and laboratory studies have demonstrated downstream mechanisms by which sleep restriction impairs glucose metabolism, including reduced insulin sensitivity. However, sleep restriction in both free-ranging humans and prior experimental studies is accompanied by longer exposure to Artificial Light At Night (ALAN), an endocrine disruptor that can profoundly disrupt circadian rhythmicity. We will evaluate the extent to which ALAN-induced endocrine and circadian disruption is a primary upstream toxic exposure contributing to the sleep-restriction- induced impairment of glucose metabolism and consequent increase in diabetes risk.
Funding type: research
Funder scheme: R01
Start date: 2021-07-29
End date: 2025-04-30
Investigator: CHARLES A CZEISLER
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 12
Funder award ID: R01DK127254
OpenAlex ID: G1089753726