Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults
Description: Project Narrative This project addresses the global problem of chronic venous leg ulcers (CVLUs), recurring wounds causing considerable infirmity for an estimated 9.7 million people every year - mainly older adults with comorbidities. The project tests a new oral therapy containing the bioactive elements of fish oil, eicosapentaenoic acid and docosahexaenoic acid, for targeting and reducing the high numbers of activated polymorphonuclear leukocytes in ulcer microenvironments that keep CVLUs “trapped” in a chronic inflammatory state and prevent healing. The project findings are expected to advance wound healing science and lead to a new low-risk adjunct oral therapy to stimulate healing of CVLUs in aging and as such, reduce the high healthcare costs associated with treatments and mitigate the negative impact CVLUs have on quality of life in aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2018-09-30
End date: 2025-04-30
Investigator: JODI CHRISTINE MCDANIEL
Institution: OHIO STATE UNIVERSITY
Funded outputs count: 5
Funder award ID: R01AG059981
OpenAlex ID: G7107588234