Award

U.1052.00.0013

Funder: Medical Research Council

Funded outputs count: 28

Funder award ID: U.1052.00.0013

OpenAlex ID: G8376115369

Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer’s Neuropathology but Are Not Independently Related to Dementia

2026 · Irina Vazquez-Villaseñor, Bridget Benson, et al. · International Journal of Molecular Sciences

VCING Scoring and White Matter Arteriolosclerosis Show Relationships to Dementia Status and White Matter Damage in an Unselected Ageing Brain Cohort

2026 · S. B. Wharton, C. D. Richardson, et al. · Neuropathology and Applied Neurobiology

Ranking and filtering of neuropathology features in the machine learning evaluation of dementia studies

2024 · Mohammed D. Rajab, Teruka Taketa, et al. · Brain Pathology · 1

Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort

2024 · Hemant Mistry, Connor D. Richardson, et al. · Neuroscience Research · 5

Insights into the pathological basis of dementia from population‐based neuropathology studies

2023 · Stephen B. Wharton, Julie E. Simpson, et al. · Neuropathology and Applied Neurobiology · 26

Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection

2023 · Mohammed D. Rajab, Emmanuel Jammeh, et al. · Alzheimer s Research & Therapy · 18

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia

2023 · Emma Nichols, Richard Merrick, et al. · The Lancet Healthy Longevity · 107

LATE-NC staging in routine neuropathologic diagnosis: an update

2022 · Peter T. Nelson, Edward B. Lee, et al. · Acta Neuropathologica · 176

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

2022 · Peter T. Nelson, Carol Brayne, et al. · Acta Neuropathologica · 176

Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection

2022 · Mohammed D Rajab, Emmanuel Jammeh, et al. · Research Square · 2

Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection

2022 · Mohammed D Rajab, Emmanuel Jammeh, et al. · medRxiv · 1

Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies

2020 · Rachel Waller, Ruth Narramore, et al. · Brain Pathology · 16

Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia

2020 · Matthew MacGregor Sharp, Satoshi Saito, et al. · Acta Neuropathologica Communications · 28

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches

2019 · on behalf of the Cognitive Function and Ageing Neuropathology Study Group, S. B. Wharton, et al. · Acta Neuropathologica Communications · 28

Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations

2019 · Santiago Coelho, Jose M. Pozo, et al. · Data in Brief · 1

Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions

2019 · Rachel Waller, Lynne Baxter, et al. · PLoS ONE · 111

Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter

2018 · Santiago Coelho, Jose M. Pozo, et al. · NeuroImage · 19

Microinfarcts in an older population‐representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease

2016 · P. G. Ince, T. Minett, et al. · Neuropathology and Applied Neurobiology · 54

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study

2016 · on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group, Stephen B. Wharton, et al. · Acta Neuropathologica Communications · 59

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

2015 · Adeline Fluteau, Paul G. Ince, et al. · Neuroscience Letters · 65

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of A lzheimer‐type pathology

2015 · Julie E. Simpson, Paul G. Ince, et al. · Neuropathology and Applied Neurobiology · 46

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

2015 · Ryan Mathur, Paul G. Ince, et al. · PLoS ONE · 52

A neuronal DNA damage response is detected at the earliest stages of A lzheimer's neuropathology and correlates with cognitive impairment in the M edical R esearch C ouncil's C ognitive F unction and A geing S tudy ageing brain cohort

2014 · Julie E. Simpson, Paul G. Ince, et al. · Neuropathology and Applied Neurobiology · 56

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

2014 · Sufana Al‐Mashhadi, Julie E. Simpson, et al. · Brain Pathology · 85

Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer’s Disease

2014 · Antigoni Ekonomou, George M. Savva, et al. · Biological Psychiatry · 79