Cryopreservation and nanowarming enables whole liver banking for transplantation, cell therapy and biomedical research
Description: PROJECT NARRATIVE Nearly one-third of deceased donor livers ultimately go unused due to the inability to preserve them long enough. We aim to develop a novel technology for indefinitely preserving whole livers in an extremely low-temperature vitrified (glass-like) state and subsequently using nanotechnology to rewarm them on demand. If successful, this novel technology will enable the banking, or “off-the-shelf” availability, of livers for transplantation and other vital biomedical applications such as cell therapy, biomedical research, and drug discovery.
Funding type: research
Funder scheme: R01
Start date: 2023-02-15
End date: 2027-01-31
Investigator: JOHN C BISCHOF
Institution: UNIVERSITY OF MINNESOTA
Funded outputs count: 18
Funder award ID: R01DK132211
OpenAlex ID: G9000861913