The molecular imaging study for the mechanism of the Deep brain stimulation in MPTP treated monkey
Description: To clarify the mechanism of the deep brain stimulation (DBS), we performed the PET study in the MPTP treated monkey by the tracer of H_2^<15>O to measure the regional cerebral blood flow (rCBF). We found the rCBF of medial superior frontal gyrus, supplementary motor cotex, superior parietal lobule and thalamus in the DBS side, the anterior cerebellar cortex in the contralateral side significantly increased, which gave an evidence that the mechanism of STN-DBS lies in the correcting the overactivation of motor controlling network.In order to clarify the dynamic variation pattern of dopamine transporter (DAT) and D^2 receptor after the dopamine depletion, which greatly influences the efficiency of DBS, we studied the variation of pre-synaptic DA transporter and post-synaptic D^2-like receptor in nigrostriatal DA system using binding assay, behavioral test and a small animal PET. Our data showed that there was a same tendency of the striatal DA transporter decrease both in MFB lesion rats and striatal lesion rats 4 weeks after lesion, however, it showed increase (up-regulation) of D^2-like receptor in the MFB lesion rats, whereas showed decrease (down-regulation) in the striatal lesion rat. This finding strongly indicated the dynamic variation pattern of DAT and D^2 receptor after the dopamine depletion should be taken into account in the molecular imaging study in PD animal models.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Investigator: Xin FANG
Institution: Hamamatsu University School of Medicine
Funded outputs count: 32
Funder award ID: 20791025
OpenAlex ID: G8399922039