Studies of TRAF3 in age-related low-level chronic inflammation and osteoporosis
Description: PUBLIC HEALTH RELEVANCE: Our new findings indicate that inflammatory factors called cytokines, whose levels increase with aging, degrade a protein, TRAF3, that regulates intracellular signaling by these cytokines, resulting in age-related osteoporosis in mice due to the increased bone destruction and inhibition of bone formation. In this proposal, we plan to investigate the molecular mechanisms whereby TRAF3 is degraded in bone forming cells, and use animal models to test if a small molecular compound, that is able to prevent cytokine-induced TRAF3 degradation, can prevent age-associated osteoporosis.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2016-01-01
End date: 2022-12-31
Investigator: BRENDAN F BOYCE (lead)
Institution: University of Rochester
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 27
Funder award ID: R01AG049994
OpenAlex ID: G8406796147