Elucidation of organ crosstalk in cardiovascular disease
Description: Heart failure pandemic has become an important medical and social burden world-wide. We previously showed that chronic inflammation initiated in obese visceral adipose tissue activates inflammation in distant tissues, such as the pancreas and heart, and promotes cardiovascular and metabolic disease. In this study we analyzed the mechanism that link the heart and kidneys in cardiorenal syndrome. We found that the heart-brain-kidney organ networks is crucial for proper response to cardiac stress. Dysfunction in this system impairs adaptation to cardiac stress, resulting in heart failure.
Amount: ¥17,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Ichiro Manabe
Institution: Chiba University
Funded outputs count: 6
Funder award ID: 16H05295
OpenAlex ID: G8407386458