Redoxome - Redox Processes in Biomedicine
Description: The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, proteomics and metabolomics of oxidative stress. Thus, a multidisciplinary approach has become essential for meaningful advances in the field. Also, emerging groups have difficulty to address relevant points and sharpen educational skills. The main purpose of our Redoxome CEPID is to foster integrative collaborations, promote sustained development and assist emerging groups. Our goal is to perform studies that allow the design and assessment of novel antioxidant strategies with clinical applicability. We will address issues relevant toward overcoming limitations in knowledge of redox processes, as follows: 1) ROS generation and control in biological systems; 2) chemical reactivity of reactive oxygen species (ROS) in biological environments and consequent changes in structure and function of biomolecules; 3) mechanism and networks involved in redox signaling processes relevant to human disease. 4) diagnostic and therapeutic applications of redox processes. These strategies will enable, on a national basis, a concerted effort to attack key questions bridging meaningful gaps in the field. Our efforts will foster integration of multiple disciplines and institutions in our country and result in advances with educational, scientific, environmental and socioeconomic impact. (AU)
Funding type: grant
Funder scheme: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Start date: 2013-09-01
End date: 2026-08-31
Investigator: Ohara Augusto
Institution: Universidade de São Paulo (USP). Instituto de Química (IQ)
Funded outputs count: 242
Funder award ID: 13/07937-8
OpenAlex ID: G8427623360