Neuroinflammation and behavior in the aged
Description: PROJECT NARRATIVE The goal of the proposed research is to determine if oxidative stress caused by a dysfunctional antioxidant homeostatic response leads to microglial cell priming in the senescent brain. Our specific hypothesis is that dysfunctional Nuclear factor E2-related factor 2 (Nrf2) signaling is responsible for microglial cell priming and increased basal inflammation in the senescent brain and that activation of Nrf2 with sulforaphane-a naturally occurring compound in cruciferous vegetables-will prevent the harmful exaggerated neuroinflammatory response and resultant behavioral pathology during peripheral infection. The proposed research is important for developing new strategies for protecting cognitive health in older adults.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2000-04-01
End date: 2017-06-30
Investigator: RODNEY W JOHNSON
Institution: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 65
Funder award ID: R01AG016710
OpenAlex ID: G5218429092