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Aging and Resiliency in Mice: Optimizing Assessment Protocols and Testing Interventions

Description: PROJECT NARRATIVE The ability of an organism to adequately respond to physical challenges or stress, termed resilience, may reflect its biological age before there is evidence of chronic disease or other late-life conditions. Herein, we propose to develop standardized physical challenges of resilience for laboratory mice, determine the degree to which they predict future health and longevity, and assess the extent to which they respond to innovative therapies that have been shown to delay aspects of aging.
Funding type: research
Funder scheme: R01
Start date: 2016-08-15
End date: 2022-04-30
Investigator: NATHAN K LEBRASSEUR
Institution: MAYO CLINIC ROCHESTER
Subfield: Aging
Funded outputs count: 24
Funder award ID: R01AG053832
OpenAlex ID: G5985617502
The Fifth Annual Symposium of the Midwest Aging Consortium
2024 · Brenda F Reader, Lorena Rosas, et al. · The Journals of Gerontology Series A
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The Fourth Annual Symposium of the Midwest Aging Consortium
2024 · Jinoh Kim, Rochelle Buffenstein, et al. · The Journals of Gerontology Series A · 1
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Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia
2023 · Davis A. Englund, Alyssa M. Jolliffe, et al. · JCI Insight · 35
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Physical Resilience as a Predictor of Lifespan and Late-Life Health in Genetically Heterogeneous Mice
2023 · Ashley K Brown, Daniel L Mazula, et al. · The Journals of Gerontology Series A · 5
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Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop
2022 · Herman A. Taylor, Toren Finkel, et al. · The FASEB Journal · 15
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Exercise Counters the Age-Related Accumulation of Senescent Cells
2022 · Xu Zhang, Davis A. Englund, et al. · Exercise and Sport Sciences Reviews · 63
Resilience to aging is a heterogeneous characteristic defined by physical stressors
2022 · Haoyi Lei, Derek M. Huffman, et al. · Aging Pathobiology and Therapeutics · 12
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Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function
2021 · Matthew R. Brown, Satish K. Sen, et al. · Science Advances · 55
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions
2021 · Davis A. Englund, Xu Zhang, et al. · Mechanisms of Ageing and Development · 94
Exercise reduces circulating biomarkers of cellular senescence in humans
2021 · Davis A. Englund, Ayumi E. Sakamoto, et al. · Aging Cell · 126
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Senolytics reduce coronavirus-related mortality in old mice
2021 · Christina D. Camell, Matthew J. Yousefzadeh, et al. · Science · 321
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Harnessing the effects of endurance exercise to optimize cognitive health: Fundamental insights from Dr. Mark P. Mattson
2020 · Sarah K. Jachim, Ayumi E. Sakamoto, et al. · Ageing Research Reviews · 10
Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity
2020 · Tracy K. Her, William S. Lagakos, et al. · American Journal of Physiology-Endocrinology and Metabolism · 23
The clinical impact and biological mechanisms of skeletal muscle aging
2019 · Zaira Aversa, Xu Zhang, et al. · Bone · 101
Late‐life time‐restricted feeding and exercise differentially alter healthspan in obesity
2019 · Marissa J. Schafer, Daniel L. Mazula, et al. · Aging Cell · 22
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Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
2019 · Allyson K. Palmer, Ming Xu, et al. · Aging Cell · 659
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TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells
2018 · Bin Zhang, Bei Liu, et al. · Channels · 8
Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
2017 · Matthew J. Yousefzadeh, Marissa J. Schafer, et al. · Aging Cell · 114
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Physical Resilience: Opportunities and Challenges in Translation
2017 · Nathan K. LeBrasseur · The Journals of Gerontology Series A · 41
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Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?
2017 · Yoginee Sritharen, Maurice Enriquez-Sarano, et al. · Physiology · 43
Cellular senescence mediates fibrotic pulmonary disease
2017 · Marissa J. Schafer, Thomas A. White, et al. · Nature Communications · 1,613
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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
2017 · Grace Casaclang-Verzosa, Maurice Enriquez-Sarano, et al. · Journal of Visualized Experiments · 15
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High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver
2016 · Dan Zhou, Ryan A. Hlady, et al. · Epigenetics · 52
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Cellular senescence: Implications for metabolic disease
2016 · Marissa J. Schafer, Jordan D. Miller, et al. · Molecular and Cellular Endocrinology · 83
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