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调肝启枢化浊法调控宿主-肠道菌群对话干预糖脂代谢紊乱的作用及机制研究

Amount: ¥2,940,000
Funding type: research
Funder scheme: 重点项目
Start date: 2018-01-01
End date: 2023-12-31
Investigator: 姣 郭
Institution: 广东药科大学
Funded outputs count: 48
Funder award ID: 81830113
OpenAlex ID: G8519449022
Single-cell transcriptomics reveals EpCAM regulates the development and morphology of intestinal epithelium via controlling the EGFR pathway
2026 · Zili Lei, Ya Nie, et al. · Genes & Diseases
Aucubin ameliorates atherosclerosis by modulating tryptophan metabolism and inhibiting endothelial-mesenchymal transitions via gut microbiota regulation
2024 · Zhizhong Luo, Ling Yang, et al. · Phytomedicine · 28
Hydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE −/− mice by inhibiting the SphK1 / S1P / S1PR3 pathway
2024 · Yuqing Liu, Jingyu Piao, et al. · Food Science & Nutrition · 10
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Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetic kidney disease in mice via inhibiting the SGLT2/glycolysis pathway
2024 · Ziyang Lin, Hongyan Huo, et al. · Journal of Ethnopharmacology · 13
Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism
2024 · Xu Li, Pingdong Cai, et al. · Metabolites · 20
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The Roles of Exosome-Derived microRNAs in Cardiac Fibrosis
2024 · Xinyuan Tang, Mingyang Leng, et al. · Molecules · 17
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The blockade of the TGF ‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity
2024 · Wen‐Dong Xu, Shui‐Zheng Lai, et al. · Pharmacology Research & Perspectives · 6
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The mediation and interaction of the obesity index between moderate-vigorous recreational physical activity and hypertension
2023 · Bingqian Du, Yuting Li, et al. · PLoS ONE · 4
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Network pharmacology combined with molecular docking and experimental verification to elucidate functional mechanism of Fufang Zhenzhu Tiaozhi against type 2 diabetes mellitus
2023 · Bo Li, Xinying Li, et al. · Journal of Biomolecular Structure and Dynamics · 9
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Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study
2023 · Huixia Zhan, Xinyu Liu, et al. · Journal of Orthopaedic Surgery and Research · 39
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Tianhuang formula ameliorates non-alcoholic fatty liver diseases in type 2 diabetic mice through CRLS1-ATF3/ChREBP pathway
2023 · Yi Han, Yating Zhao, et al. · Journal of Holistic Integrative Pharmacy · 1
Equol, a metabolite of gut microbiota, attenuates liver steatosis via the SIRT1/HNF4α pathway in NAFLD mice
2023 · Zhizhong Luo, Ling Yang, et al. · Journal of Functional Foods · 12
Tianhuang formula regulates adipocyte mitochondrial function by AMPK/MICU1 pathway in HFD/STZ-induced T2DM mice
2023 · Duosheng Luo, Yaru Zhao, et al. · BMC Complementary Medicine and Therapies · 12
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The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice
2023 · Meiling Yan, Suping Liu, et al. · Biomedicine & Pharmacotherapy · 26
Metaflammation in glucolipid metabolic disorders: Pathogenesis and treatment
2023 · Pingjie Xiong, Fan Zhang, et al. · Biomedicine & Pharmacotherapy · 59
Application of machine learning in Chinese medicine differentiation of dampness-heat pattern in patients with type 2 diabetes mellitus
2023 · Xinyu Liu, Xiaoqiang Huang, et al. · Heliyon · 7
Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation
2023 · Huiyi Li, Qiqing Weng, et al. · Food & Function · 108
Tianhuang formula regulates adipocyte mitochondrial function by AMPK/MICU1 pathway in STZ-induced T2DM mice
2022 · Duosheng Luo, Yaru Zhao, et al. · Research Square
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Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis
2022 · Xiaoqi Shao, Bingying Huang, et al. · Evidence-based Complementary and Alternative Medicine · 3
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Ginsenoside Rb1 improves intestinal aging via regulating the expression of sirtuins in the intestinal epithelium and modulating the gut microbiota of mice
2022 · Zili Lei, Lei Chen, et al. · Frontiers in Pharmacology · 15
Tianhuang formula reduces the oxidative stress response of NAFLD by regulating the gut microbiome in mice
2022 · Duosheng Luo, Ling Yang, et al. · Frontiers in Microbiology · 35
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Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice
2022 · Siyuan Xu, Bixian Ye, et al. · Frontiers in Pharmacology · 9
Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet
2022 · Zhe Chen, Bin Yang, et al. · Frontiers in Cellular and Infection Microbiology · 11
EpCAM deficiency causes premature aging of intestinal epithelium via hyperactivating mTORC1 pathway
2022 · Zili Lei, Lei Chen, et al. · Clinical and Translational Medicine · 3
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
2022 · Meiling Yan, Yun Li, et al. · Cell Death Discovery · 269
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