Epigenetic Mechanisms of Inflammation and Fatigue in Head and Neck Cancer Patients
Description: PUBLIC HEALTH RELEVANCE: Cancer-related fatigue is one of the most common and debilitating consequences of cancer and its treatment and can last for months to years after treatment completion. The proposed research is designed to examine whether persistent fatigue in patients with head and neck cancer stems from chronic inflammation secondary to epigenetic changes that result from treatment with chemo radiotherapy. The findings will identify new epigenetic mechanisms and biomarkers for fatigue and novel epigenetic targets for pharmacologic and/or behavioral fatigue therapies.
Funding type: research
Funder scheme: R01
Start date: 2016-04-22
End date: 2020-09-30
Investigator: CANHUA XIAO
Institution: EMORY UNIVERSITY
Funded outputs count: 23
Funder award ID: R01NR015783
OpenAlex ID: G2447692330