Mammary Adipocyte Remodeling in Health and Disease
Description: Breastfeeding is beneficial for both mother and child; however, mothers with obesity and type 2 diabetes often have insufficient milk production. We hypothesize that adipocytes in the breast tissue interact with the mammary epithelial cells to undergo dramatic remodeling, with play critical roles in establishing breastfeeding, as well as post-weaning lactation suppression and cessation. Our findings will provide fundamental knowledge to the fields of both adipose and mammary gland biology, provide novel insights into lactation and involution complications in women with metabolic disorders.
Funding type: research
Funder scheme: R01
Start date: 2020-04-14
End date: 2026-02-28
Investigator: QIONG ANNABEL WANG
Institution: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
Funded outputs count: 10
Funder award ID: R01HD096152
OpenAlex ID: G7891515377