Exploring the biology ofÃÂ O-acetylÃÂ sialic acids using stable syntheticÃÂ mimics
Description: Project Narrative Exploring the biology of O-acetyl sialic acids using stable synthetic mimics This proposal brings together experts in chemistry and biology of sialic acids as well as theoretical chemistry to solve long-standing problems with the instability of a modification of cell surface sialic acids called O- acetylation, allowing analysis of the roles of this important glycan modification in biological and pathological conditions. Stable N-acetyl analogs will be synthesized and used to investigate various sialic acid-binding proteins and microorganisms using multiple methods.
Funding type: research
Funder scheme: R01
Start date: 2017-09-25
End date: 2022-08-31
Investigator: XI CHEN
Institution: UNIVERSITY OF CALIFORNIA AT DAVIS
Funded outputs count: 55
Funder award ID: R01AI130684
OpenAlex ID: G4863234872