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GABA对胰岛β细胞及糖代谢调节作用的机制研究

Amount: ¥2,750,000
Funding type: research
Funder scheme: 重点项目
Start date: 2016-01-01
End date: 2021-12-31
Investigator: 庆华 王
Institution: 复旦大学
Funded outputs count: 14
Funder award ID: 81630020
OpenAlex ID: G8651226382
Antiaging Properties of the Klotho Protein
2026 · Gérald J. Prud’homme, Qinghua Wang · Cells · 2
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GABA induces myokine irisin release from skeletal muscle
2026 · Linling Fan, Yijing Liao, et al. · Life Sciences · 1
GABA ameliorates diet‐induced hepatic steatosis and insulin resistance by inhibiting macrophage activation
2025 · Qiaoli Cui, Qiwei Yang, et al. · Diabetes Obesity and Metabolism · 12
Irisin Alleviates Impaired Mitochondrial Fusion via Enhancing PKA/SIRT3/mTOR Pathway in Hepatic Steatosis
2025 · Jia Li, Ying Zhao, et al. · Journal of Gastroenterology and Hepatology · 6
Klotho protects INS-1 pancreatic β-cells from senescence and enhances mitochondrial function
2025 · Zhihong Wang, Yunzhi Ni, et al. · Frontiers in Aging · 5
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Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging
2024 · Gérald J. Prud'homme, Qinghua Wang · Cells · 69
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Causal effects of non-alcoholic fatty liver disease on osteoporosis: a Mendelian randomization study
2023 · Yue Zhou, Yunzhi Ni, et al. · Frontiers in Endocrinology · 6
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Metabolomics analysis of islet regeneration in partial pancreatectomy mice reveals increased levels of long-chain fatty acids and activated cAMP signaling pathway
2023 · Di Wu, Yaojing Jiang, et al. · Biochemical and Biophysical Research Communications · 2
Combined therapy of GABA and sitagliptin prevents high-fat diet impairment of beta-cell function
2022 · Zhihong Wang, Linling Fan, et al. · Molecular and Cellular Endocrinology · 8
Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
2022 · Gérald J. Prud’homme, Mervé Kurt, et al. · Frontiers in Aging · 225
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Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression
2021 · Yaojing Jiang, Lu Zhu, et al. · FEBS Journal · 8
GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects
2019 · Qinghua Wang, Liwei Ren, et al. · Journal of Cellular Physiology · 59
Combined effect of GABA and glucagon‐like peptide‐1 receptor agonist on cytokine‐induced apoptosis in pancreatic β‐cell line and isolated human islets
2018 · Dong Ok Son, Wenjuan Liu, et al. · Journal of Diabetes · 28
Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival
2018 · Junfeng Li, Zhihong Wang, et al. · Cell Communication and Signaling · 9
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