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Deciphering the cellular origins and impact of toxic formaldehyde in mammalian cells

Description: PROJECT NARRATIVE Mammalian cells produce high levels of a reactive toxic chemical called formaldehyde. This proposal sets out to identify the health-relevant life factors that trigger endogenous formaldehyde production and characterize how excess cellular formaldehyde can damage cell function.
Amount: $2,071,000
Funding type: research
Funder scheme: R35
Start date: 2025-08-15
End date: 2029-07-31
Investigator: MENG WANG
Institution: CORNELL UNIVERSITY
Funded outputs count: 3
Funder award ID: 1r35gm160077-01
OpenAlex ID: G8707202959
2026 · Allen F. Schroeder, Yan Yu, et al. · ACS Chemical Biology · 1
2026 · Christopher Mellor, Brandon T James, et al. · EMBO Molecular Medicine
2026 · Brandon T. James, Emma P. Kosmeder, et al. · Biomolecules
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