Identification of novel cooperating partners of MYCN in neuroblastoma tumorigenesis
Description: PUBLIC HEALTH RELEVANCE MYCN has been known as a genetic driver of neuroblastoma for the past three decades, but no clinically relevant inhibitors have been developed to target MYCN directly due to its biochemical structure. To address this issue, we propose to develop the first human stem-cell based model of neuroblastoma to test candidate cooperating partners of MYCN in promoting neuroblastoma tumorigenesis, which will provide clues of possible druggable targets.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R00
Start date: 2016-07-01
End date: 2023-08-31
Investigator: MILLER HUANG
Institution: CHILDREN'S HOSPITAL OF LOS ANGELES
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 7
Funder award ID: R00CA197484
OpenAlex ID: G5262804602