miR-181b, endothelial cells, and vascular inflammation
Description: Narrative: Vascular senescence due to DNA damage is an emerging characteristic feature seen in atherosclerosis and other chronic disease states, an effect that may promote disease progression leading to heart attack, stroke, or peripheral vascular disease. We identified an endothelial-enriched microRNA (miRNA) that is dynamically expressed with atherosclerosis in young and old mice, and may act to control lesion formation within the vessel wall by controlling DNA damage and cell senescence. The proposed studies will provide a detailed understanding underlying the function of this miRNA, its target genes and interactomes, and how to restore its expression therapeutically with the goal of developing novel miRNA-based therapies for the treatment of vascular senescence and atherosclerotic cardiovascular disease.
Funding type: research
Funder scheme: R01
Start date: 2012-08-01
End date: 2026-07-31
Investigator: MARK W FEINBERG
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Funded outputs count: 80
Funder award ID: R01HL115141
OpenAlex ID: G5940811367