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FGF21 is an endocrine signal of protein restriction

Description: PUBLIC HEALTH RELEVANCE: This project focuses on the molecular mechanisms connecting dietary macronutrient composition and metabolism. Our data identify FGF21 as a critical endocrine signal for dietary protein restriction. This project will further test this funcional relationship by definitively determining whether FGF21 is an essential mediator of the metabolic and behavioral responses to dietary protein restriction. This project will exert a significant and sustained impact on the field by identifying molecular detectors of protein availability, redefinin the physiological role of FGF21, and identifying new dietary and molecular strategies for the regulation of metabolism.
Funding type: research
Funder scheme: R01
Start date: 2015-12-01
End date: 2020-11-30
Investigator: CHRISTOPHER D MORRISON
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Funded outputs count: 30
Funder award ID: R01DK105032
OpenAlex ID: G8785580167
FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging
2026 · Jose A. Godoy-Lugo, Khristina E. Young, et al. · npj Aging
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Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK ‐ ULK1 ‐Mediated Mitochondrial Quality Control
2026 · Wagner S. Dantas, Elizabeth R. M. Zunica, et al. · Aging Cell · 4
Hepatic interoception in health and disease
2024 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Autonomic Neuroscience · 16
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FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
2022 · Cristal M. Hill, Diana C. Albarado, et al. · Nature Communications · 117
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FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
2021 · McNulty, Margaret A., Goupil, Brad A., et al. · Civil War Book Review · 1
Learning of food preferences: mechanisms and implications for obesity & metabolic diseases
2021 · Hans-Rudolf Berthoud, Christopher D. Morrison, et al. · International Journal of Obesity · 73
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FGF21 prevents low-protein diet-induced renal inflammation in aged mice
2021 · Han Fang, Sujoy Ghosh, et al. · American Journal of Physiology-Renal Physiology · 20
Brain Protein Synthesis and Cell Proliferation in Sulfur Amino Acid Restricted Mice
2021 · Wenceslao Martinez, Qian Zhang, et al. · The FASEB Journal
Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex
2020 · William O Jonsson, Nicholas S Margolies, et al. · Journal of Nutrition · 35
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The obesity epidemic in the face of homeostatic body weight regulation: What went wrong and how can it be fixed?
2020 · Hans-Rudolf Berthoud, Christopher D. Morrison, et al. · Physiology & Behavior · 53
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FGF21 and the Physiological Regulation of Macronutrient Preference
2020 · Cristal M Hill, Emily Qualls-Creekmore, et al. · Endocrinology · 99
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Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice
2020 · Christopher D. Morrison, Cristal M. Hill, et al. · Journal of Diabetes and its Complications · 22
FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
2019 · Margaret A. McNulty, Brad A. Goupil, et al. · Bone Reports · 4
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FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
2019 · Cristal M. Hill, Thomas Laeger, et al. · Cell Reports · 229
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Gastric bypass surgery in lean adolescent mice prevents diet-induced obesity later in life
2019 · Michael B. Mumphrey, Zheng Hao, et al. · Scientific Reports · 8
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice
2019 · Brandon B. Boland, Michael B. Mumphrey, et al. · Molecular Metabolism · 36
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The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery
2019 · Brandon Boland, Michael B. Mumphrey, et al. · Nutrients · 39
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Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice
2019 · Camille Allard, Fabrice Bonnet, et al. · Molecular Metabolism · 58
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Homeostatic sensing of dietary protein restriction: A case for FGF21
2018 · Cristal M. Hill, Hans-Rudolf Berthoud, et al. · Frontiers in Neuroendocrinology · 68
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Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice
2018 · Zheng Hao, R. Leigh Townsend, et al. · Obesity Surgery · 33
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Preoptic leptin signaling modulates energy balance independent of body temperature regulation
2018 · Sangho Yu, Helia Cheng, et al. · eLife · 48
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Dietary branched chain amino acids and metabolic health: when less is more
2018 · Cristal M. Hill, Christopher D. Morrison · The Journal of Physiology · 12
Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
2017 · Cristal M. Hill, Thomas Laeger, et al. · Scientific Reports · 97
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Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion
2017 · Emily Qualls-Creekmore, Sangho Yu, et al. · Journal of Neuroscience · 121
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Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms
2017 · Hans-Rudolf Berthoud, Heike Münzberg, et al. · Gastroenterology · 446
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