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The Role of Uromodulin in the Regulation of the Renal Calcium Channel TRPV5

Description: Elevated calcium levels in human urine, called hypercalciuria, are a significant risk factor for kidney stones. Mouse models carrying Uromodulin (Umod) mutations display significant hypercalciuria but only limited understanding about the function of UMOD exists. This proposal seeks to improve our knowledge how UMOD, the most abundant protein in urine, modifies calcium channels in the kidney in order to better treat kidney stones.
Funding type: career_development
Funder scheme: K08
Start date: 2012-09-01
End date: 2017-05-31
Investigator: MATTHIAS TILMANN FLORIAN WOLF
Institution: UT SOUTHWESTERN MEDICAL CENTER
Field: Medicine
Funded outputs count: 11
Funder award ID: K08DK095994
OpenAlex ID: G4174390484
Uromodulin in mineral metabolism
2019 · Matthias T.F. Wolf, Jing Zhang, et al. · Current Opinion in Nephrology & Hypertension · 31
Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)
2018 · Mingzhu Nie, Manjot S. Bal, et al. · Journal of Biological Chemistry · 60
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Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly
2017 · Daniela A Braun, Jia Rao, et al. · Nature Genetics · 221
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Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome
2017 · Natalie Ellington, Matthias T. F. Wolf, et al. · International Journal of Surgical Pathology
Inherited and acquired disorders of magnesium homeostasis
2016 · Matthias Tilmann Florian Wolf · Current Opinion in Pediatrics · 26
Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients
2016 · Mingzhu Nie, Manjot S. Bal, et al. · Journal of the American Society of Nephrology · 58
Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management—A KDIGO consensus report
2015 · Kai-Uwe Eckardt, Seth L. Alper, et al. · Kidney International · 371
Nephronophthisis and related syndromes
2015 · Matthias T.F. Wolf · Current Opinion in Pediatrics · 148
Klotho Up-regulates Renal Calcium Channel Transient Receptor Potential Vanilloid 5 (TRPV5) by Intra- and Extracellular N-glycosylation-dependent Mechanisms
2014 · Matthias T.F. Wolf, Sung-Wan An, et al. · Journal of Biological Chemistry · 69
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Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis
2013 · Matthias T.F. Wolf, Xue-Ru Wu, et al. · Kidney International · 77
Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies
2012 · Bodo B Beck, Anne Baasner, et al. · European Journal of Human Genetics · 79
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