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DK102142

Funded outputs count: 49
Funder award ID: DK102142
OpenAlex ID: G8796728975
Differentiating hepatic and renal toxicity reveals CYP-independent mechanisms of acetaminophen-induced acute kidney injury
2026 · Yasaman Etemadi, Timothy A. Fields, et al. · Toxicology
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The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure
2025 · David S Umbaugh, Nga T Nguyen, et al. · Toxicological Sciences · 1
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The multiple mechanisms and modes of cell death after acetaminophen overdose
2025 · Hartmut Jaeschke, Anup Ramachandran · Exploration of Digestive Diseases · 10
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Reactive oxygen species and peroxynitrite in acetaminophen-induced liver injury: Lipid peroxidation and ferroptosis-like cell death
2025 · Hartmut Jaeschke, Anup Ramachandran · Ferroptosis and Oxidative Stress
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Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models
2024 · Hartmut Jaeschke, Anup Ramachandran · Toxicological Sciences
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Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective
2024 · Hartmut Jaeschke, Anup Ramachandran · Journal of Clinical and Translational Hepatology · 18
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Effect of ferroptosis inhibitors in a murine model of acetaminophen‐induced liver injury
2024 · Olamide B. Adelusi, Yasaman Etemadi, et al. · Journal of Biochemical and Molecular Toxicology · 17
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Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress
2024 · Hartmut Jaeschke, Anup Ramachandran · Drug Metabolism and Disposition · 51
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The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration
2024 · David S. Umbaugh, Nga T. Nguyen, et al. · Toxicology · 26
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
2024 · Olamide B. Adelusi, Jephte Y. Akakpo, et al. · Archives of Toxicology · 7
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Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure
2024 · Anup Ramachandran, Jephte Y. Akakpo, et al. · Biochemical Pharmacology · 62
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects
2024 · Hartmut Jaeschke, Anup Ramachandran · Phytotherapy Research
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Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury
2024 · Hartmut Jaeschke, Anup Ramachandran · Annual Review of Pathology Mechanisms of Disease · 247
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Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight
2024 · David S Umbaugh, Hartmut Jaeschke · Expert Review of Clinical Pharmacology · 8
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Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose
2023 · Giselle Sanchez-Guerrero, David S. Umbaugh, et al. · Livers
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Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine
2023 · Jephte Y. Akakpo, Anup Ramachandran, et al. · Toxicology · 25
The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure
2023 · David S. Umbaugh, Nga T. Nguyen, et al. · Hepatology · 23
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Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane
2023 · Yasaman Etemadi, Jephte Y. Akakpo, et al. · Journal of Biochemical and Molecular Toxicology · 21
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Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review
2023 · Anup Ramachandran, Hartmut Jaeschke · Livers · 34
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Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice
2023 · Nga T. Nguyen, David S. Umbaugh, et al. · Archives of Toxicology · 38
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Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice
2022 · Hartmut Jaeschke, Anup Ramachandran · Microbiology Spectrum
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
2022 · Jephte Y. Akakpo, Anup Ramachandran, et al. · Archives of Toxicology · 115
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice
2021 · Nga T. Nguyen, David S. Umbaugh, et al. · Archives of Toxicology · 56
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
2021 · Hartmut Jaeschke, Olamide B. Adelusi, et al. · Acta Pharmaceutica Sinica B · 148
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Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole
2021 · Jephte Y. Akakpo, Matthew W. Jaeschke, et al. · Archives of Toxicology · 48
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