Thymic Rejuvenation for the Induction of Transplantation Tolerance
Description: Studies in a large animal model have demonstrated: 1) that a juvenile thymus is required for the induction of tolerance to vascularized renal allografts by a short course of immunosuppressive drugs; and 2) that the aged thymus can be restored to its juvenile state by transplantation into a young recipient, indicating that factors outside of the thymus are responsible for this rejuvenation. This proposal is directed toward determining what these factors are so that they may be used to rejuvenate the thymus of adult animals and thereby render them susceptible to tolerance induction by the same simple treatment regimen that is effective in juveniles. .
Funding type: research
Funder scheme: R01
Start date: 2010-01-15
End date: 2014-12-31
Investigator: DAVID H SACHS
Institution: MASSACHUSETTS GENERAL HOSPITAL
Funded outputs count: 12
Funder award ID: R01AI086134
OpenAlex ID: G1040951137