A molecular mechanism of aging through epigenome and muscle regeneration
Description: ICE (Induced changes in epigenome) mice is a novel mouse model in which aging related phenotypes and the changes in epigenome are induced by DNA damage through I-PpoI endonuclease. By induction of DNA damage for three weeks at 4 to 6 months age in mice, muscle mass and muscle functions are declined at 10 months post-treatment. Transcriptome analysis with RNA-seq showed ribosomal genes (RPS28 and RPS 24), OXPHOS genes (ATP5k, Ndufa8, COX8) and myosin-related genes (Myh7, Myh9) are altered at 10 month after induction of aging along with changes in H3K4me1 and H4K20me1 at those genes in ICE mice. Those data indicate that LSD1 and SETD8 invloved in regulation of aging and muscle function during aging.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2019-03-31
Investigator: Motoshi Hayano
Institution: Keio University
Funded outputs count: 3
Funder award ID: 17K13228
OpenAlex ID: G8865217745