Succinate signaling in periodontitis induced neuroinflammation and dementia
Description: Project Narrative Periodontitis is chronic gum inflammation leading to systemic inflammation and neuroinflammation and may subsequently promote the pathogenesis of Alzheimer’s disease. The proposed study will identify a novel mechanism by which periodontitis increases succinate in cerebrospinal fluid and activates succinate receptor in microglia to induce neuroinflammation and neurodegeneration. The study will provide a potential therapeutic strategy by targeting succinate receptor.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-01-01
End date: 2027-12-31
Investigator: XIN LI
Institution: UNIVERSITY OF VIRGINIA
Funded outputs count: 4
Funder award ID: R01AG080696
OpenAlex ID: G9000884784