Mechanisms and consequences of plasma membrane damage
Description: The first cell on earth was composed of genetic materials surrounded by membrane. Therefore, plasma membrane repair is fundamental to life. Although plasma membrane repair is involved in a variety of diseases, underlying mechanisms remained unclear. We found that plasma membrane damage induces activation of the cell cycle checkpoint via the degradation of DNA replication machinery as well as stabilization of cell cycle inhibitors. Severer plasma membrane damage contributes to cellular senescence and apoptosis. Normal cells and cancer cells behaved differently after plasma membrane damage. These results may contribute to the development of new cancer therapies in the future.
Amount: ¥17,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Keiko Kono
Institution: Okinawa Institute of Science and Technology Graduate University
Funded outputs count: 4
Funder award ID: 17H04045
OpenAlex ID: G8887047481