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Integrin Function in Cartilage

Description: Osteoarthritis is the most common cause of chronic disability in older adults but treatments to slow the progression of the disease are lacking. The results from this project will provide new information about basic mechanisms relevant to cartilage breakdown in osteoarthritis. This information is needed in order to discover new targets and develop new therapies for slowing or stopping the progression of the disease.
Funding type: research
Funder scheme: R37
Start date: 2002-08-01
End date: 2023-07-31
Investigator: RICHARD F LOESER
Institution: UNIV OF NORTH CAROLINA CHAPEL HILL
Subfield: Rheumatology
Field: Medicine
Funded outputs count: 58
Funder award ID: R37AR049003
OpenAlex ID: G3003429331
Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes
2025 · Seyoun Byun, Jacqueline Shine, et al. · Nature Communications · 4
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Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk
2025 · Nicole E. Kramer, Seyoun Byun, et al. · Cell Genomics · 23
Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes
2024 · Seyoun Byun, Philip Coryell, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype
2024 · Rachel Gagliardi, Drew W. Koch, et al. · Journal of Orthopaedic Research®
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Integrin signalling in joint development, homeostasis and osteoarthritis
2024 · Michael Z. Miao, Janice S. Lee, et al. · Nature Reviews Rheumatology · 48
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Use of a novel magnetically actuated compression system to study the temporal dynamics of axial and lateral strain in human osteochondral plugs
2023 · Matthew J. Rich, Sarah Burnash, et al. · Journal of Biomechanics · 2
Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis
2023 · Michael Z. Miao, Qian Peter Su, et al. · Science Signaling · 35
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Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes
2023 · Y. Cui, M.Z. Miao, et al. · Osteoarthritis and Cartilage · 24
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3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes
2022 · Eliza Thulson, Eric S Davis, et al. · Genetics · 17
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Correspondence on ‘Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7'
2022 · Richard F Loeser, Philip R Coryell · Annals of the Rheumatic Diseases
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Diagnosis and Treatment of Hip and Knee Osteoarthritis
2021 · Jeffrey N. Katz, Kaetlyn R. Arant, et al. · JAMA · 2,336
Optimization of histologic grading schemes in spontaneous and surgically-induced murine models of osteoarthritis
2021 · A.R. Armstrong, C.S. Carlson, et al. · Osteoarthritis and Cartilage · 31
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CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways
2021 · Helen Willcockson, Huseyin Ozkan, et al. · Osteoarthritis and Cartilage Open · 18
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Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype
2020 · K.S.M. Reed, V. Ulici, et al. · Osteoarthritis and Cartilage · 40
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
2020 · Philip R. Coryell, Brian O. Diekman, et al. · Nature Reviews Rheumatology · 762
Role of the Hypoxia-Inducible Factor Pathway in Normal and Osteoarthritic Meniscus and in Mice after Destabilization of the Medial Meniscus
2020 · Austin V. Stone, Richard F. Loeser, et al. · Cartilage · 4
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JNK Pathway as a Target for Osteoarthritis: Comment on the Article by Loeser et al
2020 · Wang‐Dong Xu, An‐Fang Huang · Arthritis & Rheumatology · 1
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2020 · Richard F. Loeser, John A. Collins, et al. · Arthritis & Rheumatology
Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice
2020 · Richard F. Loeser, Kathryn L. Kelley, et al. · Arthritis & Rheumatology · 38
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
2020 · Steven Tessier, Alexandra C. Doolittle, et al. · JCI Insight · 30
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TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis
2019 · Tieshi Li, Susan Chubinskaya, et al. · Science Translational Medicine · 64
Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2
2019 · Veronica Ulici, Kathryn L. Kelley, et al. · American Journal Of Pathology · 12
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Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling
2018 · J.A. Collins, L. Arbeeva, et al. · Osteoarthritis and Cartilage · 15
H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes
2018 · Kimberly J. Nelson, Jesalyn A. Bolduc, et al. · Journal of Biological Chemistry · 49
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Reactive oxygen species, aging and articular cartilage homeostasis
2018 · Jesalyn A. Bolduc, John A. Collins, et al. · Free Radical Biology and Medicine · 658
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