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Senolytic and Senostatic Drugs for the Treatment of Angiotensin Ii-induced Reactive Cardiac Fibrosis

Amount: CLP 222,100
Funding type: research
Funder scheme: FONDECYT - REGULAR
Start date: 2021-01-01
End date: 2025-12-31
Investigator: GUILLERMO DIAZ ARAYA
Institution: UNIVERSIDAD DE CHILE
Funded outputs count: 51
Funder award ID: 1210627
OpenAlex ID: G8892784977
Simultaneous induction of differentiation and senescence in cardiac fibroblasts by TGF-β1: effects of senotherapeutics drugs
2026 · Claudio Espinoza-Perez, José Miguel Osorio, et al. · Frontiers in Pharmacology
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Resolvin D1 attenuates senescence-associated secretory phenotype independently of TGF-β–driven cardiac fibroblasts differentiation to myofibroblast
2026 · Mauricio Román, José Miguel Osorio, et al. · Journal of Inflammation
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Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts
2023 · Renatto Anfossi, Raúl Vivar, et al. · Frontiers in Cell and Developmental Biology · 9
Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1β
2022 · Jenaro A. Espitia-Corredor, Licia Shamoon, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 37
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Regulation of BMP8A expression during hepatic fibrogenesis process
2022 · Águeda González Rodríguez, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain, et al. · IBJ Plus
A unique F-actin and junctional organization that maintains the corneal endothelial barrier
2022 · Centro de Biología Molecular Severo Ochoa-CSIC, UAM, Madrid, Madrid, Spain, G Cerro-Tello, et al. · IBJ Plus
In vivo nanotracer for the detection of brain thrombi in an AD mouse model.
2022 · Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernandez Almagro 3, Madrid, Spain., Valentín Fuster, et al. · IBJ Plus
Dmrt5 beyond the cortex: early role in the sexual differentiation of the mouse limbic system.
2022 · Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Program of Tissue and Organ Homeostasis, Madrid, Spain., Rafael Casado-Navarro, et al. · IBJ Plus
Early use of corticosteroids and sarilumab in SARS-Cov-2 pneumonia.
2022 · AF Caballero-Bermejo, A Sancho-López, et al. · IBJ Plus
Obesity-associated renal alterations are mediated by Microsomal Prostaglandin E Synthase-1 (mPGES-1) in a sex-dependent manner.
2022 · C Ballesteros-Martinez, R Rodrigues-Diez, et al. · IBJ Plus
Clinical and Immunometabolic Patterns Determining Efficacy of DCtreatment reinvigorating HIV-1-specific CD8+ T cells in PLWH
2022 · IBJ Plus
Regulation of β-amyloid clearance in APP/PS1 astrocytes by AMPK activation and MTORC1 inhibition
2022 · Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), C/Nicolas Cabrera 1, Universidad Autónoma de Madrid, Madrid 28049, Spain, Lara Ordóñez-Gutiérrez, et al. · IBJ Plus
Neutralizing serum amyloid A1 as a therapeutic strategy for traumatic brain injury
2022 · Céline Decouty Pérez, Instituto Teófilo Hernando de I+D del Medicamento, Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, España., et al. · IBJ Plus
Automatic synapse parameter exploration for the interaction of living neurons and models in hybrid circuits and hybrots
2022 · Grupo de Neurocomputación, Manuel Reyes-Sanchez, et al. · IBJ Plus
Use of anti-GD2 (Dinutuximab) as a target for CAR-T cells immunotherapy in neuroblastoma
2022 · Lorena García-García, Keren Pastora, et al. · IBJ Plus
Background: Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide, being nonalcoholic steatohepatitis (NASH) its most clinically relevant form. Given the risks associated with taking a liver biopsy, the design of accurate non-invasive methods to identify NASH patients is of upmost importance. BMP2 plays a key role in metabolic homeostasis; however, little is known about its involvement in NAFLD onset and progression. This study aimed to elucidate the impact of BMP2 in NAFLD pathophysiology. Methods: Hepatic and circulating levels of BMP2 were quantified in serum and liver specimens from 115 biopsyproven NAFLD patients and 75 subjects with histologically normal liver (NL). In addition, BMP2 content and release was determined in cultured human hepatocytes upon palmitic acid (PA) overload. Results: We found that BMP2 expression was abnormally increased in livers from NAFLD patients than in subjects with NL and this was reflected in higher serum BMP2 levels. Notably, we observed that PA upregulated BMP2 expression and secretion by human hepatocytes. An algorithm based on serum BMP2 levels and clinically relevant variables to NAFLD showed an AUROC of 0.886 (95%CI, 0.83–0.94) to discriminate NASH. We used this algorithm to develop SAN (Screening Algorithm for NASH): a SAN < 0.2 implied a low risk and a SAN ≥ 0.6 indicated high risk of NASH diagnosis. Conclusion: This proof-of-concept study shows BMP2 as a new molecular target linked to NAFLD and introduces SAN as a simple and efficient algorithm to screen individuals at risk for NASH.
2022 · Instituto Cajal, Avenida Doctor Arce 37, Madrid, Spain., Cristina Martín-Monteagudo, et al. · IBJ Plus
Unravelling neuron-astrocyte communication in the dorsal raphe nucleus.
2022 · Andrea Sánchez-Ruiz, Candela González-Arias1, et al. · IBJ Plus
Gasdermin B over-expression modulates HER2-targeted therapy resistance through LC3B/Rab7 interaction
2022 · Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ", Manuel Gámez-Chiachio, et al. · IBJ Plus
Association of mutant spectra of SARS-CoV-2 with COVID-19 disease severity
2022 · Brenda Martínez-González, María Eugenia Soria, et al. · IBJ Plus
Alteration of PGC1-α in the mitochondrial homeostasis of cardiomyocytes under hyperglycemia. Role of the GLP-1R activation
2022 · Jairo Lumpuy-Castillo, Tianyu Hang, et al. · IBJ Plus
The Sonic Hedgehog Agonist Sag Attenuates Mitochondrial Dysfunction and Decreases the Neurotoxocity Induced by Frataxin-deficient Astrocytes
2022 · Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Andrés Vicente-Acosta, et al. · IBJ Plus
Multiplex Immunofluorescence reveals specific subsets of immune cell populations expressing CD137/TNFRSF9 as predictors of unfavorable outcomes in Hodgkin Lymphoma
2022 · José L Solórzano, Victoria Menéndez, et al. · IBJ Plus
Resolvin E1 attenuates endothelial senescence induced by doxorubicin through the modulation of NLRP3 inflammasome activation.
2022 · Licia Shamoon, Instituto de Investigaciones Sanitarias (IdiPAZ), Madrid, Spain., et al. · IBJ Plus
Targeted endothelial knockout of caveolin-1 in established atherosclerosis does not inhibit plaque progression
2022 · Experimental Pathology of Atherosclerosis Lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Rocío Muñiz-Anquela, et al. · IBJ Plus
Generation and characterization of the adult neuron-specific Aralar/AGC1 knock-out mice.
2022 · Departamento de Biologia Molecular. Universidad Autónoma de Madrid (UAM), Madrid, Spain., Eduardo Herrada, et al. · IBJ Plus
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