Redecoding viral genes
Description: The gene products of the virus are synthesized in the host during viral infections and they cause various diseases. Defining the complete set of translated genes is essential to understand viral pathogenesis and for the development of antiviral drugs and vaccines. Thus, mapping the translated sequences in viral genomes is critical. However, in viral genomes, the coding information tends to be densely packaged with a variety of non-canonical translational elements. These elements usually lack well-defined sequence signatures, making it difficult to annotate translated sequences by traditional annotation approaches based on sequences. Therefore, new approaches to comprehensively detect the viral translational status of infected cells are required for strengthening countermeasures to viral infections. In this study, we devised a novel approach to comprehensively identify yet-to-be decoded viral protein coding genes.
Amount: ¥6,500,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2017-06-30
End date: 2020-03-31
Investigator: Akihisa Kato
Institution: The University of Tokyo
Funded outputs count: 4
Funder award ID: 17K19549
OpenAlex ID: G8895658393