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AG038072

Funded outputs count: 38
Funder award ID: AG038072
OpenAlex ID: G8909779965
Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes
2026 · Raquel Gómez-Sintes, Inmaculada Tasset, et al. · Proceedings of the National Academy of Sciences · 1
Reduced IGF-1 signaling fails to limit Alzheimer’s disease progression in a novel rat model of IGF-1R haploinsufficiency
2025 · Sushma Narayan, Kai Mao, et al. · Scientific Reports · 2
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Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges
2024 · Jiahn Choi, Leonard H. Augenlicht · Experimental & Molecular Medicine · 98
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Intestinal stem cell aging at single-cell resolution: functional perturbations alter cell developmental trajectory reversed by gerotherapeutics
2022 · Jiahn Choi, Michele Houston, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
2022 · Raquel Gomez-Sintes, Qisheng Xin, et al. · Nature Communications · 54
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Evidence for preserved insulin responsiveness in the aging rat brain
2022 · Matthew G. Engel, Jeremy Smith, et al. · GeroScience · 8
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Extending human healthspan and longevity: a symposium report
2021 · Loren M. DeVito, Nir Barzilai, et al. · Annals of the New York Academy of Sciences · 58
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
2021 · Benjamin Caballero, Mathieu Bourdenx, et al. · Nature Communications · 223
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Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome
2020 · Michel Bernier, Dylan Harney, et al. · npj Aging and Mechanisms of Disease · 26
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Disulfiram Treatment Normalizes Body Weight in Obese Mice
2020 · Michel Bernier, Sarah J. Mitchell, et al. · Cell Metabolism · 85
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Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
2020 · S. Dong, C. Aguirre-Hernandez, et al. · Nature Communications · 79
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Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
2019 · Arsun Bektas, Shepherd H. Schurman, et al. · Aging · 116
Proteome-wide analysis of chaperone-mediated autophagy targeting motifs
2019 · Philipp Kirchner, Mathieu Bourdenx, et al. · PLoS Biology · 257
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Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A
2018 · Marta Pajares, Ana I Rojo, et al. · Autophagy · 222
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Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease
2018 · Ken Y. Hui, Heriberto Fernandez-Hernandez, et al. · Science Translational Medicine · 386
Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity
2017 · Yotam Raz, Ignacio Guerrero-Ros, et al. · The Journals of Gerontology Series A · 63
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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
2016 · Sarah J. Mitchell, Julio Madrigal-Matute, et al. · Cell Metabolism · 451
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AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
2016 · Susmita Kaushik, Ana Maria Cuervo · Autophagy · 273
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Common γ-chain cytokine signaling is required for macroautophagy induction during CD4 + T-cell activation
2015 · Yair Botbol, Bindi Patel, et al. · Autophagy · 59
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Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
2015 · Susmita Kaushik, Ana Maria Cuervo · Nature Cell Biology · 720
Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
2015 · Caroline Park, Yousin Suh, et al. · Nature Communications · 224
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Huntingtin functions as a scaffold for selective macroautophagy
2015 · Yan-Ning Rui, Zhen Xu, et al. · Nature Cell Biology · 423
Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
2015 · Jaime L. Schneider, Joan Villarroya, et al. · Aging Cell · 191
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Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles
2015 · Wenge Li, R. Brent Calder, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 34
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation
2014 · Rut Valdor, Enric Mocholi, et al. · Nature Immunology · 244
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