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Ion channels in the tubulovesicles

Description: The outcome of our proposed research should provide clinical insights into therapeutic approaches for acid-related gastric diseases.
Funding type: research
Funder scheme: R01
Start date: 2017-12-01
End date: 2024-11-30
Investigator: MOHAMMED AKAABOUNE
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Funded outputs count: 15
Funder award ID: R01DK115474
OpenAlex ID: G4103079999
The Acid Gate in the Lysosome
2022 · Meiqin Hu, Jingzhi Chen, et al. · Autophagy · 104
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Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
2022 · Meiqin Hu, Ping Li, et al. · Cell · 250
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
2020 · Ping Li, Meiqin Hu, et al. · Proceedings of the National Academy of Sciences · 73
Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
2020 · Dan Li, Rong Shao, et al. · Autophagy · 172
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models
2020 · Lu Yu, Xiaoli Zhang, et al. · Science Advances · 66
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Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels
2019 · Xiaoli Zhang, Wei Chen, et al. · eLife · 53
Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
2019 · Taylor F. Minckley, Chen Zhang, et al. · Nature Communications · 46
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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6
2019 · Yi Xin, Allison Malick, et al. · eLife · 27
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
2019 · Xiaoli Zhang, Wei Chen, et al. · PLoS Biology · 102
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Lysosomal Ion Channels as Decoders of Cellular Signals
2018 · Ping Li, Mingxue Gu, et al. · Trends in Biochemical Sciences · 175
Organellar TRP channels
2018 · Xiaoli Zhang, Meiqin Hu, et al. · Nature Structural & Molecular Biology · 74
Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
2018 · Zhen Wang, Ramon Ocadiz-Ruiz, et al. · Journal of Visualized Experiments · 26
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Release and uptake mechanisms of vesicular Ca2+ stores
2018 · Junsheng Yang, Zhuangzhuang Zhao, et al. · Protein & Cell · 99
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Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells
2017 · Sinju Sundaresan, Cameron A. Meininger, et al. · Gastroenterology · 37
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Organización espacial de los sedimentos en conos aluviales del Pirineo Central Español
1998 · Amelia Gómez‐Villar, José M. García‐Ruiz · Boletín de la Real Sociedad Española de Historia Natural. Sección geológica
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