Award

Proteomic aging in adults before and after cancer diagnosis

Description: PROJECT NARRATIVE This proposal is of great public health and clinical importance because understanding the role of aging in cancer risk and outcomes in cancer survivors may inform on novel strategies for risk-stratified cancer screening and surveillance. An accurate blood-based measurement of biological aging in cancer will provide a tool that will help facilitate the development of anti-aging therapies before and after cancer diagnosis.p 1

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2022-08-01

End date: 2025-07-31

Investigator: ANNA PRIZMENT

Institution: UNIVERSITY OF MINNESOTA

Funded outputs count: 13

Funder award ID: R01CA267977

OpenAlex ID: G8945036261

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts

2026 · Oliver Robinson, Han Xiao, et al. · Nature Aging · 2

A Novel Longitudinal Proteomic Aging Index Predicts Mortality, Multimorbidity, and Frailty in Older Adults

2025 · Zexi Rao, Shuo Wang, et al. · Aging Cell · 5

Biological organ ages associate with risk of chronic diseases in a community-based population

2025 · Celina S. Liu, Wan-Jin Yeo, et al. · JCI Insight · 3

Proteomic aging clocks and the risk of mortality among long-term cancer survivors

2025 · Shuo Wang, Zexi Rao, et al. · JNCI Journal of the National Cancer Institute · 2

Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)

2025 · Oliver Robinson, Han Xiao, et al. · Research Square

Aging measures and cancer in the Health and Retirement Study (HRS)

2025 · Shuo Wang, Anna Prizment, et al. · Nature Communications · 13

Associations of social network size and perceived level of social support with age acceleration estimated by a proteomic aging clock: the Atherosclerosis Risk in Communities Study

2025 · Eri Eguchi, Anna Prizment, et al. · American Journal of Epidemiology

Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer

2025 · Matia Solomon, R Bhatia, et al. · Journal of Cancer Survivorship · 1

The Association between Proteomic Aging Clocks and the Risk of Cancer in Midlife Individuals

2025 · Shuo Wang, Zexi Rao, et al. · medRxiv

Frailty and pre-frailty associated with long-term diminished physical performance and quality of life in breast cancer and hematopoietic cell transplant survivors

2024 · Najla El Jurdi, Hok Sreng Te, et al. · Aging · 8

Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts

2024 · Shuo Wang, Zexi Rao, et al. · PLoS Medicine · 25

Implementation and impact of an electronic patient reported outcomes system in a phase II multi-site adaptive platform clinical trial for early-stage breast cancer

2024 · Anna Northrop, Anika Christofferson, et al. · Journal of the American Medical Informatics Association · 2

Accelerated Aging in Cancer Survivors: Cellular Senescence, Frailty, and Possible Opportunities for Interventions

2024 · Shuo Wang, Najla El Jurdi, et al. · International Journal of Molecular Sciences · 33