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Relationships between APP and Mitochondria

Description: Project Narrative Mitochondrial dysfunction and failure of mitochondrial degradation pathways (mitophagy) are observed in Alzheimer’s diseases (AD) and likely contribute to pathogenesis. Amyloid precursor protein (APP) localizes to mitochondria and affects mitochondrial and mitophagy function. We will directly test the relationship between APP, mitophagy, and mitochondrial function.
Funding type: research
Funder scheme: R01
Start date: 2023-05-01
End date: 2028-01-31
Investigator: HEATHER M. WILKINS
Institution: UNIVERSITY OF KANSAS MEDICAL CENTER
Funded outputs count: 13
Funder award ID: R01AG078186
OpenAlex ID: G9000866222
APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology
2026 · Colton R. Lysaker, Chelsea N. Johnson, et al. · npj Dementia · 10
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APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD ‐Like Pathology, Cognition, and Mitochondrial Function
2026 · Chelsea N. Johnson, Colton R. Lysaker, et al. · FASEB BioAdvances
Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization
2026 · Aadrita Chatterjee, Brian Alvarez, et al. · Alzheimer s & Dementia
APOE4 drives widespread changes to the hepatic proteome and alters metabolic function
2026 · Colton R. Lysaker, Chelsea N. Johnson, et al. · iScience · 9
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The impact of exercise on brain mitochondrial health and its relevance to Alzheimer's disease
2025 · Vivien Csikos, John P Thyfault, et al. · Brain and Environment · 6
Evaluating the Causal Effect of Mitochondrial Dysfunction on Alzheimer’s and Parkinson’s Disease using Polygenic Risk Scores and Mendelian Randomization
2025 · Aadrita Chatterjee, Brian Alvarez, et al. · Alzheimer s & Dementia · 1
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Amyloid-β protein precursor modulates mitophagy and mitochondrial function through its cellular localization
2025 · Taylor A Strope, Benjamin Troutwine, et al. · Journal of Alzheimer s Disease · 1
Charting the future: current and future directions in translational research for individuals with Down syndrome
2025 · Katherine A. Waugh, Heather M. Wilkins, et al. · Journal of Neurodevelopmental Disorders · 8
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O-GlcNAc impacts mitophagy via the PINK1-dependent pathway
2024 · Ibtihal M. Alghusen, Marisa S. Carman, et al. · Frontiers in Aging Neuroscience · 21
The reciprocal relationship between amyloid precursor protein and mitochondrial function
2024 · Taylor A. Strope, Heather M. Wilkins · Journal of Neurochemistry · 15
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Intrinsic aerobic capacity modulates Alzheimer’s disease pathological hallmarks, brain mitochondrial function and proteome during aging
2024 · Benjamin A. Kugler, Colton R. Lysaker, et al. · GeroScience · 18
Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease
2023 · Kaitlin Flannagan, Julia A. Stopperan, et al. · Frontiers in Molecular Neuroscience · 25
Editorial: Systemic implications of Alzheimer's disease
2023 · Constanza J. Cortes, John P. Thyfault, et al. · Frontiers in Aging Neuroscience · 5
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