The development of MRI-based non-invasive biomarkers to investigate the effect of vascular risk factors on the glymphatic system
Description: Metabolic syndrome (MetS) has recently been linked to reduced removal of brain waste products, leading to cognitive decline and motor impairment. Our study aims to: (A) develop and validate noninvasive MRI-based biomarkers for elucidating the effect of MetS or its components on glymphatic system compartments; (B) predict subjects with MetS or its components at risk of developing glymphatic dysfunction-related cognitive decline and motor impairment; and (C) clarify vascular and modifiable lifestyle risk factors of glymphatic dysfunction for integrating preventive and therapeutic strategies.
Amount: ¥4,680,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2023-04-01
End date: 2026-03-31
Investigator: クリスティーナ アンディカ
Institution: Juntendo University
Funded outputs count: 12
Funder award ID: 23K14927
OpenAlex ID: G898616960