Basic research for the development of new preventive and therapeutic methods for vascular diseases targeting GM1
Description: In order to examine the effect of inflammatory stimulation, which is a cause of various diseases in individual aging, on vascular endothelial cells, I examined the expression and function of ganglioside after treatment with different concentrations of TNFα for different time intervals for mimicking in vivo acute or chronic inflammatory situations. As a result, it was clarified that the expression of GM1 among various gangliosides was increased dependent on concentration of TNFα and was found to be involved in the decrease in insulin signaling. When exposed to high concentrations of TNFα, GM1 expression-dependent insulin resistance was observed even after removal of TNFα. In this study, we obtained new findings as a molecular mechanism of GM1-regulated vascular insulin resistance.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-10-21
End date: 2020-03-31
Investigator: Norihiko Sasaki
Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Funded outputs count: 22
Funder award ID: 16K08263
OpenAlex ID: G899156819