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Metabolic Basis of Disease - Phase 2

Description: Project Narrative: The overall goal of this Phase 2 Metabolic Basis of Disease center is to continue to facilitate the growth of young intellectual talent, foster collaborations, and enhance the scientific infrastructure to promote biomedical research discoveries that will enhance our understanding of the metabolic aspects of various disease states.
Funding type: program
Funder scheme: P20
Start date: 2020-03-01
End date: 2030-07-31
Investigator: JACQUELINE M STEPHENS
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Funded outputs count: 115
Funder award ID: P20GM135002
OpenAlex ID: G9000866203
Combination of genetic eNOS deficiency and high-fat diet induces reproducible cardiometabolic HFpEF
2026 · Mahmoud H. Elbatreek, Vinayak S. Khodade, et al. · Redox Biology
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Multiomics approaches reveal direct NF-κB p65 target genes in pancreatic islets during cytokine exposure and in type 1 diabetes
2026 · Thomas M. Martin, Susan J. Burke, et al. · American Journal of Physiology-Endocrinology and Metabolism
FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging
2026 · Jose A. Godoy-Lugo, Khristina E. Young, et al. · npj Aging
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Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β cell maturity
2026 · J. Jason Collier, Caroline R. Cothern, et al. · JCI Insight
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Vagal sensory neurons profusely innervate the mouse gall bladder
2026 · Winfried L. Neuhuber, Sangho Yu, et al. · Autonomic Neuroscience
Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus
2026 · Heike Münzberg, Jaclyn Williams, et al. · The Journal of Comparative Neurology
An Artemisia scoparia Extract and Rosiglitazone Have Distinct but Overlapping Effects on Adipocyte Function
2026 · Anik Boudreau, Lindsey Yoo, et al. · Obesity · 1
FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction
2026 · Redin A. Spann, Sora Q. Kim, et al. · Cell Reports · 3
Obesity and Heart Failure With Preserved Ejection Fraction: A Clinical Nexus for Exercise Intolerance
2026 · Abhishek Pandit, Mahima Gupta, et al. · Obesity · 2
Unveiling ribosomal dysfunction and impaired signaling pathways in the cortical region of 5xFAD mice
2026 · Kirti Agrawal, Blessing C. Egbejiogu, et al. · Acta Neuropathologica Communications · 1
Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK ‐ ULK1 ‐Mediated Mitochondrial Quality Control
2026 · Wagner S. Dantas, Elizabeth R. M. Zunica, et al. · Aging Cell · 4
Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma
2025 · Melina C. Mancini, Cameron P. McCall, et al. · Oncogenesis · 3
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Protocol for measuring in vivo, ex vivo, and in vitro glucose uptake in brown adipocytes
2025 · Chul-Hong Park, Ji Suk Chang · STAR Protocols
Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity
2025 · Rea Victoria P. Anunciado-Koza, M. Elena Martinez, et al. · Frontiers in Endocrinology · 1
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Interleukin-6 blockade does not impair exercise-induced glucose uptake and insulin sensitivity in rheumatoid arthritis
2025 · Andresa Rossilho Casale, Ítalo Ribeiro Lemes, et al. · American Journal of Physiology-Endocrinology and Metabolism
Low protein-induced-FGF-21 signaling remodels adipose tissue on reduced markers of senescence during aging
2025 · Jose G. Godoy-Lugo, Khristina E. Young, et al. · GeroScience · 3
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Dysregulated Protein s -Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction
2025 · Zhen Li, Kyle B. LaPenna, et al. · Circulation Research · 14
Integrative Raman Spectroscopy and Multi-Omics Analysis of Lipid and Matrix Protein Heterogeneity in Triple-Negative Breast Cancer
2025 · Elnaz Sheikh, Khudeja Salim, et al. · Chemical & Biomedical Imaging · 2
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF
2025 · Jake E. Doiron, Mahmoud H. Elbatreek, et al. · JACC Basic to Translational Science · 9
The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation
2025 · Chul-Hong Park, Minsung Park, et al. · Frontiers in Cell and Developmental Biology
Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner
2025 · Pei Luo, Xiaohua Yang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids
2025 · Chul-Hong Park, Minsung Park, et al. · Cell Reports · 16
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High-Protein Diet Prevents Glucocorticoid-Induced Fat Mass Accumulation and Hyperglycemia
2025 · Susan J. Burke, Heidi M. Batdorf, et al. · International Journal of Molecular Sciences
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FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction
2025 · Redin A. Spann, Sora Q. Kim, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice
2025 · Meng Yu, Bing Feng, et al. · Nature Metabolism · 6
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