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Genes contributing for nicotine dependence in humans

Description: Addiction is a common and costly public health problem, and tobacco use is the leading cause of preventable deaths in the US. Understanding the genetic basis of nicotine dependence has enormus public health relevance, as the project has already demonstrated by identifying several genetic variants conferring risk of both nicotine dependence and lung cancer.
Funding type: research
Funder scheme: R01
Start date: 2005-08-01
End date: 2018-06-30
Investigator: KARI STEFANSSON
Institution: DECODE GENETICS, EHF
Funded outputs count: 33
Funder award ID: R01DA017932
OpenAlex ID: G5175413258
Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk
2022 · Wenjun Yang, Hongliang Liu, et al. · npj Precision Oncology · 7
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Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
2020 · Bryan C. Quach, Michael J. Bray, et al. · Nature Communications · 119
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The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
2019 · Jonathan R.I. Coleman, Héléna A. Gaspar, et al. · Biological Psychiatry · 199
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Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis
2019 · Ying Zhu, Yongyue Wei, et al. · Cancer Epidemiology Biomarkers & Prevention · 32
Shared heritability and functional enrichment across six solid cancers
2019 · Xia Jiang, Hilary K. Finucane, et al. · Nature Communications · 110
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer
2017 · Yun Feng, Yanru Wang, et al. · Molecular Carcinogenesis · 10
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence
2017 · D B Hancock, Y Guo, et al. · Molecular Psychiatry · 135
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Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis
2017 · Snaevar Sigurdsson, Kristjan F. Alexandersson, et al. · Nature Communications · 89
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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
2017 · Florian Zink, Simon N. Stacey, et al. · Blood · 777
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Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium
2017 · Yun Feng, Yanru Wang, et al. · Scientific Reports · 15
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Functional variants in DCAF4 associated with lung cancer risk in European populations
2017 · Hongliang Liu, Zhensheng Liu, et al. · Carcinogenesis · 20
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Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs
2017 · Yongchu Pan, Hongliang Liu, et al. · Scientific Reports · 15
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Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
2017 · Gunnar W. Reginsson, Andres Ingason, et al. · Addiction Biology · 112
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Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
2016 · Min-Tzu Lo, David A Hinds, et al. · Nature Genetics · 444
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Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk—A re‐analysis of eight GWASs
2016 · Fei Zhou, Yanru Wang, et al. · Molecular Carcinogenesis · 10
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer
2016 · Hua Yuan, Hongliang Liu, et al. · Scientific Reports · 46
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The rate of meiotic gene conversion varies by sex and age
2016 · Bjarni V Halldorsson, Marteinn T Hardarson, et al. · Nature Genetics · 101
A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences
2016 · T E Thorgeirsson, S Steinberg, et al. · Molecular Psychiatry · 33
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Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14 463 cases and 44 188 controls
2016 · Xiaozheng Kang, Hongliang Liu, et al. · Carcinogenesis · 10
From paper to web: Mode equivalence of the ARHQ and NEO-FFI
2014 · Gyda Bjornsdottir, Anna B. Almarsdottir, et al. · Computers in Human Behavior · 6
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
2014 · Yufei Wang, James D McKay, et al. · Nature Genetics · 454
Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction
2013 · Gyda Bjornsdottir, Fridrik H. Jonsson, et al. · Personality and Individual Differences · 23
A common biological basis of obesity and nicotine addiction
2013 · T E Thorgeirsson, D F Gudbjartsson, et al. · Translational Psychiatry · 71
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Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers
2012 · Sarah M. Hartz, Susan E. Short, et al. · Archives of General Psychiatry · 75
Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption
2011 · Patrick Sulem, Daniel F. Gudbjartsson, et al. · Human Molecular Genetics · 145
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