Investigating the Role of PLIN2 in Senescence
Description: NARRATIVE The goal of this application is to elucidate the role of the lipid droplet and PLIN2 in the initiation and maintenance of the senescence phenotype. This work is significant as PLIN2 has clearly been shown to modulate inflammatory states but its ability to regulate the proinflammatory phenotype of senescence has yet to be established. By focusing on this novel niche in senescence, this proposal will lay the groundwork establishing PLIN2 and the LD as central to senescence and its associated inflammatory secretome, thus unveiling a novel mechanism by which senescence contributes to tissue dysfunction.
Funder: National Institute on Aging
Funding type: fellowship
Funder scheme: F30
Start date: 2022-07-05
End date: 2025-12-24
Investigator: MAHIMA DEVARAJAN
Institution: UNIVERSITY OF MINNESOTA
Funded outputs count: 2
Funder award ID: F30AG076322
OpenAlex ID: G9000902059