Homeostasis functions of SKN-1A/Nrf1
Description: Narrative The model organism C. elegans has proven to be invaluable for discovery of mechanisms that influence aging and metabolism. Here we will build upon our recent work in C. elegans to determine how the master gene regulator SKN-1A/Nrf1 responds to the unsaturated fat oleic acid to benefit the organism and increase lifespan. We will also determine how stress in the protein synthesis machinery alters metabolism, and why this gene regulator is then protective, work that will provide fundamental insights into mechanisms that maintain protein synthesis and may suggest strategies for treating the human genetic disease Diamond- Blackfan anemia.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2017-03-01
End date: 2028-05-31
Investigator: JEAN E. SCHAFFER (lead)
Institution: Joslin Diabetes Center
Funded outputs count: 22
Funder award ID: R01AG054215
OpenAlex ID: G9000887409