Signaling mechanisms that detect stress and maintain homeostasis
Description: Project Narrative Responses to metabolic and other stresses play critical roles in development, many diseases, and aging. This project investigates how specific defenses against reactive oxygen species (ROS), metabolic stress, and misfolded proteins are regulated so that they respond to stress and other signals appropriately, including how they influence protein oxidation to maintain cellular function, resist stress, and ensure longevity.
Funding type: research
Funder scheme: R35
Start date: 2017-07-20
End date: 2027-08-31
Investigator: C RONALD KAHN
Institution: JOSLIN DIABETES CENTER
Funded outputs count: 25
Funder award ID: R35GM122610
OpenAlex ID: G9000908001